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Phentolamine Mesylate

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Phentolamine Mesylate Product details

Name: Phentolamine Mesylate

Synonyms: Phentolamine methanesulfonate salt; 3-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]

phenol methanesulphonate

Molecular Formula: C18H23N3O4S

Molecular Weight: 377.46

CAS No.: 65-28-1

Purity: 99.0%

Packing: 25kgs/drum; 10kgs/drum; 5kgs/bag; 1kg/bag

Standards: USP32

Appearance: white or almost white crystalline powder



Phentolamine Mesylate is a reversible nonselective alpha-adrenergic antagonist. Its primary action is vasodilation due to α1 blockade. Phentolamine Mesylate also can lead to reflex tachycardia because of hypotension and α2 inhibition, which increases sympathetic tone.

The primary application for Phentolamine Mesylate is for the control of hypertensive emergencies, most notably due to pheochromocytoma. Phentolamine Mesylate is also used in the treatment of pheochromocytoma prior to the administration of beta blockers to avoid unopposed alpha-stimulation. Phentolamine Mesylate has diagnostic and therapeutic roles in complex regional pain syndrome. Phentolamine Mesylate has recently been introduced in the dental field as a local anesthetic reversal agent.

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